Nuno Matela
Room in IBEB
0.12
Contacts
E-mail: nmatela[at]ciencias.ulisboa.pt
Professional networks
Research topics
- Breast Cancer Diagnosis
- Image Analysis
- Image Processing
- Image Reconstruction
- Medical Devices
- Medical Imaging
Biography
Nuno Matela graduated in Technological Physics Engineering from Instituto Superior Técnico in 2002. After completing this degree, he enrolled in the doctoral program in Biophysics at the Faculty of Sciences of the University of Lisbon (FCUL) and completed his PhD in Biomedical Engineering and Biophysics at the same faculty in 2008.
During his PhD, he worked on the development of image reconstruction algorithms for positron emission mammography, as part of an international project that led to the construction of two prototypes for breast cancer diagnosis based on this technology.
Currently, Nuno Matela is an Assistant Professor at the Department of Physics at FCUL, coordinator of the Bachelor’s degree in Biomedical Engineering and Biophysics, member of the Pedagogical Council and member of the Ethics Committee. He was until 2023 coordinator of the PhD in Biomedical Engineering and Biophysics. He is a member of the Health Network of the University of Lisbon, representing FCUL.
Nuno Matela’s main research topic is medical imaging, in particular applications to the diagnosis of breast cancer. He is interested in topics such as breast tomosynthesis, X-ray mammography, nuclear medicine imaging, image processing and reconstruction, automatic classification and risk prediction.
Since finishing his degree, Nuno Matela has participated in 13 funded projects, supervised more than 80 master’s theses, 1 PhD thesis and is currently supervising 5 more PhD theses (4 of them with funding).
He received the award for the Recognition of Teaching Excellence at Ciências-ULisboa in the years 2017/18, 2018/19, 2020/21 and 2021/22.
Publications
Journal publications
(2023) Digital Breast Tomosynthesis: Towards Dose Reduction through Image Quality Improvement, Journal of Imaging 9(6), p. 119, MDPI, doi:10.3390/jimaging9060119
(2023) Lumbar intervertebral disc segmentation for computer modeling and simulation, Computer Methods and Programs in Biomedicine 230, p. 107337, Elsevier, doi:10.1016/j.cmpb.2023.107337
(2023) Nanoparticle-Based Treatment in Glioblastoma, Journal of Personalized Medicine 13(9), p. 1328, MDPI, doi:10.3390/jpm13091328
(2023) Highlighted Advances in Therapies for Difficult-To-Treat Brain Tumours Such as Glioblastoma, Pharmaceutics 15(3), p. 928, MDPI, doi:10.3390/pharmaceutics15030928
(2023) Avoiding Tissue Overlap in 2D Images: Single-Slice DBT Classification Using Convolutional Neural Networks, Tomography 9(1), p. 398-412, MDPI, doi:10.3390/tomography9010032
(2022) Automatic Classification of Simulated Breast Tomosynthesis Whole Images for the Presence of Microcalcification Clusters Using Deep CNNs, Journal of Imaging 8(9), p. 231, MDPI, doi:10.3390/jimaging8090231
(2022) AI in Breast Cancer Imaging: A Survey of Different Applications, Journal of Imaging 8(9), p. 228, MDPI, doi:10.3390/jimaging8090228
(2021) Tomosim: A tomographic simulator for differential optical absorption spectroscopy, Drones 5(1), p. 1-20, MDPI, doi:10.3390/drones5010003
(2021) Breast cancer risk assessment: A review on mammography-based approaches, Journal of Imaging 7(6), p. 98, MDPI, doi:10.3390/jimaging7060098
(2020) Impact of total variation minimization in volume rendering visualization of breast tomosynthesis data, Computer Methods and Programs in Biomedicine 195, p. 105534, Elsevier, doi:10.1016/j.cmpb.2020.105534
(2020) Optimization of Breast Tomosynthesis Visualization through 3D Volume Rendering, Journal of Imaging 6(7), doi:10.3390/JIMAGING6070064
(2020) An Enhanced Visualization of DBT Imaging Using Blind Deconvolution and Total Variation Minimization Regularization, IEEE Transactions on Medical Imaging 39(12), p. 4094-4101, IEEE, doi:10.1109/TMI.2020.3013107
(2020) A novel hybrid nanosystem integrating cytotoxic and magnetic properties as a tool to potentiate melanoma therapy, Nanomaterials 10(4), p. 693, MDPI, doi:10.3390/nano10040693
(2020) TomoSim: A Tomographic Simulator for DOAS, Atmospheric Measurement Techniques Discussions(May), p. 1-23, Preprints
(2020) Dose assessment and reconstruction algorithm optimization in simultaneous breast and lung CT imaging., Radiation Physics and Chemistry 176, p. 108972, Pergamon, doi:10.1016/j.radphyschem.2020.108972
(2019) Digital Breast Tomosynthesis imaging using compressed sensing based reconstruction for 10 radiation doses real data, Biomedical Signal Processing and Control 48, p. 26-34, Elsevier, doi:10.1016/j.bspc.2018.08.036
(2019) An EDUGATE simulation toolkit based on the educational easyPET, Biomedical Physics and Engineering Express 5(2), p. 25009, IOP Publishing, doi:10.1088/2057-1976/aae4d4
(2019) Noninvasive tracer kinetic analysis of brain 18F-florbetaben PET: a comparison of kinetic models, European Journal of Nuclear Medicine and Molecular Imaging 46(1), p. S768-S9, EANM'19, url
(2018) Plastic scintillation detectors for dose monitoring in digital breast tomosynthesis, Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 877, p. 346-348, North-Holland, doi:10.1016/j.nima.2017.10.021
(2018) Demo hour, Interactions 25(3), p. 8-11, ACM New York, NY, USA, doi:10.1145/3199473
(2018) Activity estimation and biokinetic analysis of 99mTc-DMSA in renal infant patients using a gamma camera, Physica Medica 52, p. 9-17, Elsevier, doi:10.1016/j.ejmp.2018.06.010
(2016) Dynamic relaxation in algebraic reconstruction technique (ART) for breast tomosynthesis imaging, Computer Methods and Programs in Biomedicine 132, p. 189-196, Elsevier, doi:10.1016/j.cmpb.2016.05.001
(2015) Total variation minimization filter for DBT imaging, Medical Physics 42(6), p. 2827-2836, doi:10.1118/1.4919680
(2015) Effect of the glandular composition on digital breast tomosynthesis image quality and dose optimisation, Radiation Protection Dosimetry 165(1-4), p. 337-341, Oxford University Press, doi:10.1093/rpd/ncv124
(2014) Image quality and dose assessment in digital breast tomosynthesis: A Monte Carlo study, Radiation Physics and Chemistry 104, p. 158-162, Pergamon, doi:10.1016/j.radphyschem.2013.12.036
(2014) PET motion correction using PRESTO with ITK motion estimation, EJNMMI Physics 1(S1), p. 1-2, Springer International Publishing, doi:10.1186/2197-7364-1-s1-a59
(2014) Optimal photon energy comparison between digital breast tomosynthesis and mammography: A case study, Physica Medica 30(4), p. 482-488, Elsevier, doi:10.1016/j.ejmp.2014.02.001
(2014) Dynamic analysis of MR-PET data on brain tumors, EJNMMI Physics 1(S1), p. 1-3, Springer International Publishing, doi:10.1186/2197-7364-1-s1-a56
(2013) Optimization of convergent collimators for pixelated SPECT systems, Medical Physics 40(6), p. 13, doi:10.1118/1.4804053
(2013) Estimation of the collective dose in the portuguese population due to medical procedures in 2010, Radiation Protection Dosimetry 154(4), p. 446-458, Oxford University Press, doi:10.1093/rpd/ncs258
(2013) Estimativa da dose coletiva na população portuguesa devido a exames médicos de radiologia de diagnóstico e de medicina nuclear, Irpa, p. 1-18
(2012) Cálculo de Doses em exames de TC Admómen-Pélvico em dois hospitais da região de Lisboa, Jornal de Investigação Biomédica e Biofarmacêutica(9), p. 55-66, pdf
(2012) 739 Cancer Therapy Models – Development of a Novel Clinically Relevant Orthotopic Xenograft Rat Model of Metastatic Colorectal Adenocarcinoma, European Journal of Cancer 48(48), p. S176, doi:10.1016/s0959-8049(12)71379-5
(2012) Relatório sobre os resultados do projecto Dose Datamed 2 Portugal, Image Wisely, p. 1-40, pdf
(2011) A Review on Recent Developments in Positron Emission Tomography Technology, Recent Patents on Medical Imaging 1(1), p. 5-25, Bentham Science Publishers, doi:10.2174/2210684711101010005
(2011) The ClearPEM breast imaging scanner, Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 628(1), p. 444-447, North-Holland, doi:10.1016/j.nima.2010.07.021
(2011) Avaliação dos n{\'\i}veis de referência de dose no estudo tomográfico do tórax, Edições Universitárias Lusófonas
(2010) Choosing the ART relaxation parameter for Clear-PEM 2D image reconstruction, Computer Methods and Programs in Biomedicine 98(2), p. 183-190, Elsevier, doi:10.1016/j.cmpb.2009.11.010
(2010) System matrix calculation for 2D image reconstruction algorithms for the clear-PEM scanner, International Journal of Tomography and Statistics 13(W10), p. 98-125
(2010) Initial Evaluation of Real Data Obtained With the Clear-PEM Scanner, Eur. J. Nucl. Med. Mol. Imaging 37, p. S309
(2009) Avaliação de Dose em radiologia pediátrica numa Unidade de Cuidados Intensivos Neonatal, Revista Lusófona de Ciências e Tecnologias da saúde(6), p. 45-55, Edições Universitárias Lusófonas, url
() Collective dose estimation in Portuguese population due to medical exams of diagnostic radiology and nuclear medicine
(2009) Optimization of 2D image reconstruction for positron emission mammography using IDL, Computers in Biology and Medicine 39(2), p. 119-129, Pergamon, doi:10.1016/j.compbiomed.2008.11.011
(2008) 2D Interative Image Reconstruction for Dual Planar Detector for Positron Emission Mammography, Engelharia biomédica e biofísica - Tese de doutoramento
(2008) Evaluation of paediatric exposure parameters and doses in 5-10 years old children. Comparison between Digital and non-digital acquisitions in frontal Thorax projection., Revista Lus{ó}fona de Ci{ê}ncias e tecnologias da Sa{ú}de 5(5), p. 152-164
(2008) Avaliação dos Parâmetros de exposição e dose em pediatria dos 5 aos 10 anos de idade. Comparaçãao entre aquisiçãao digital e nãao digital na incidêencia de torax de frente, Revista Lusófona de Ciências e Tecnologias da saúde(5), p. 152-164, Edições Universitárias Lusófonas, pdf
(2007) Avaliação dos padrões de Dose em Radiologia Pediátrica : Comparação entre Sistemas Convencionais de Películas e Sistemas de Digitalização de Imagem em crianças dos 0-5 anos de idade , na radiografia do Tórax em Incidência Comparison between Conventional F, Biomedical Sciences(4), p. 37-45, Edições Universitárias Lusófonas
(2007) Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics, Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 571(1-2 SPEC. ISS.), p. 81-84, Elsevier, doi:10.1016/j.nima.2006.10.034
(2007) Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics, Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 571(1-2 SPEC. ISS.), p. 81-84, North-Holland, doi:10.1016/j.nima.2006.10.034
(2006) Design and evaluation of the clear-PEM scanner for positron emission mammography, IEEE Transactions on Nuclear Science 53(1), p. 71-77, IEEE, doi:10.1109/TNS.2006.870173
(2005) Clear-PEM: A dedicated pet camera for improved breast cancer detection, Radiation Protection Dosimetry 116(1-4), p. 208-210, Oxford University Press, doi:10.1093/rpd/nci039
(2005) Clear-PEM: A dedicated pet camera for improved breast cancer detection, Radiation Protection Dosimetry 116(1-4), p. 208-210, doi:10.1093/rpd/nci039
(2004) Algebraic reconstruction technique (ART) using linograms, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 31, p. S271--S272, SPRINGER
() Breast Tomosynthesis Image Reconstruction using GPGPUs
(2004) Avaliação dos padrões de dose em radiologia pediátrica, Radiologia Brasileira 37(4), p. 279-282, Edições Universitárias Lusófonas, doi:10.1590/s0100-39842004000400011
(2004) Breast imaging with a dedicated PEM, Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 527(1-2), p. 87-91, North-Holland, doi:10.1016/j.nima.2004.03.081
Conference publications
(2022) Detection of Microcalcifications in Digital Breast Tomosynthesis using Faster R-CNN and 3D Volume Rendering, PROCEEDINGS OF THE 15TH INTERNATIONAL JOINT CONFERENCE ON BIOMEDICAL ENGINEERING SYSTEMS AND TECHNOLOGIES (BIOIMAGING), VOL 2, p. 80-89, doi:10.5220/0010938800003123
(2021) Perfusion-like images based on [18F]florbetaben PET correlate well with brain metabolism in patients with inherited transthyretin-related amyloidosis, European Journal of Nuclear Medicine and Molecular Imaging 48(SUPPL 1), p. S431-S432, url
(2020) Calculation of transfer functions for volume rendering of breast tomosynthesis imaging, 15th International Workshop on Breast Imaging (IWBI2020) 11513, p. 12, doi:10.1117/12.2559932
(2020) Correlation assessment between brain F-18-Florbetaben PET/CT SUVR late acquisitions and parametric images obtained from dynamic acquisitions compartmental analysis, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 47(SUPPL 1), p. S166--S167
(2019) Supporting the stratification of non-small cell lung carcinoma for Anti PD-L1 immunotherapy with digital image registration, 6th IEEE Portuguese Meeting on Bioengineering, ENBENG 2019 - Proceedings, p. 1-4, doi:10.1109/ENBENG.2019.8692525
(2018) The underrated dimension: How 3D interactive mammography can improve breast visualization, Lecture Notes in Computational Vision and Biomechanics 27, p. 329-337, doi:10.1007/978-3-319-68195-5_36
(2017) VRRRRoom: Virtual reality for radiologists in the reading room, Conference on Human Factors in Computing Systems - Proceedings 2017-May, p. 4057-4062, doi:10.1145/3025453.3025566
(2017) Implementation of maj orization-minimization (MM) algorithm for 3D total variation minimization in DBT image reconstruction, 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 2017-Janua, p. 1-5, doi:10.1109/NSSMIC.2016.8069493
(2016) 3D total variation minimization filter for breast tomosynthesis imaging, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 9699, p. 501-509, doi:10.1007/978-3-319-41546-8_63
(2016) Optimisation of DBT using parallel computing aiming to reduce patient dose
(2016) An iterative algorithm for total variation minimization in DBT imaging, Computational Vision and Medical Image Processing V - Proceedings of 5th Eccomas Thematic Conference on Computational Vision and Medical Image Processing, VipIMAGE 2015, p. 119-122, doi:10.1201/b19241-21
(2016) Radiation Monitoring System in Clinical Imaging, Bioinformatics Open Days
(2013) Scatter and attenuation corrections for a PEM detector using List-Mode OSEM, IEEE Nuclear Science Symposium Conference Record, p. 1-4, doi:10.1109/NSSMIC.2013.6829264
(2012) Modeling colorectal adenocarcinoma: A novel orthotopic xenograft metastatic cancer model with non-invasive nuclear imaging tumor evaluation, European Journal of Nuclear Medicine and Molecular Imaging 39, p. S242, url
(2012) Development of breast and tumour models for simulation of novel multimodal PEM-UWB technique for detection and classification of breast tumours, IEEE Nuclear Science Symposium Conference Record, p. 2769-2772, doi:10.1109/NSSMIC.2012.6551631
(2011) List-mode maximum-likelihood reconstruction for the ClearPEM system, IEEE Nuclear Science Symposium Conference Record, p. 4171-4174, doi:10.1109/NSSMIC.2011.6153798
(2011) Assessment of DOI resolution in a fully mounted PEM scanner, IEEE Nuclear Science Symposium Conference Record, p. 3351-3353, doi:10.1109/NSSMIC.2011.6152607
(2011) ClearPEM scanners: Performance results and studies in preclinical environment, IEEE Nuclear Science Symposium Conference Record, p. 3291-3295, doi:10.1109/NSSMIC.2011.6152592
(2009) Development of component-based normalization correction for the clear-PEM system, IEEE Nuclear Science Symposium Conference Record, p. 2846-2848, doi:10.1109/NSSMIC.2009.5401637
(2009) Targeted image reconstruction in positron emission mammography, IFMBE Proceedings 25(5), p. 358-361, doi:10.1007/978-3-642-03904-1_100
(2009) Characterization of the clear-PEM breast imaging scanner performance, IEEE Nuclear Science Symposium Conference Record, p. 3487-3490, doi:10.1109/NSSMIC.2009.5401796
(2009) High-speed data acquisition electronics for a PEM scanner, 2009 16th IEEE-NPSS Real Time Conference - Conference Record, p. 196-200, doi:10.1109/RTC.2009.5321874
(2008) Performance evaluation of a highly integrated APD/ASIC double-readout supermodule with 768 channels for clear-PEM, 2008 IEEE Nuclear Science Symposium Conference Record, p. 802-814
(2008) An overview of the clear-PEM breast imaging scanner, IEEE Nuclear Science Symposium Conference Record, p. 5616-5618, doi:10.1109/NSSMIC.2008.4774518
(2006) Evaluation of spatial resolution of planar detector PET systems: different strategies show different results, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 33, p. S89--S90
(2006) Bayesian image reconstruction for the clear-PEM Scanner, IEEE Nuclear Science Symposium Conference Record 5, p. 2940-2943, doi:10.1109/NSSMIC.2006.356492
(2005) Clear-PEM data reconstruction using STIR, Eur J Nucl Med Mol Imag 32(S1), p. S34
(2005) Comparison of different image reconstruction strategies in Clear-PEM, CIMED 05-Second International Conference on Computational Intelligence in Medicine and Healthcare, Conference Records
(2005) Reconstruction of clear-PEM data with STIR, IEEE Nuclear Science Symposium Conference Record 4, p. 2098-2102, doi:10.1109/NSSMIC.2005.1596748
(2005) First experimental results with the clear-PEM detector, IEEE Nuclear Science Symposium Conference Record 3, p. 1662-1666, doi:10.1109/NSSMIC.2005.1596639
(2005) Breast cancer imaging studies by Monte Carlo simulation with clear-PEM, IEEE Nuclear Science Symposium Conference Record 4, p. 2103-2107, doi:10.1109/NSSMIC.2005.1596749
(2005) Evaluation of Rebinning Methods in a 2D Reconstruction Scenario with Linograms for Clear-PEM, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 32, p. S256--S256
(2004) System matrix calculation for clear-PEM using ART and linograms, IEEE Nuclear Science Symposium Conference Record 4, p. 2601-2604, doi:10.1109/nssmic.2004.1462785
(2004) Design and evaluation of the clear-PEM detector for positron emission mammography, IEEE Nuclear Science Symposium Conference Record 6, p. 3805-3809, doi:10.1109/nssmic.2004.1466709
(2003) Clear-PEM: Monte Carlo performance and image reconstruction studies, IEEE Nuclear Science Symposium Conference Record 3, p. 1918-1922, doi:10.1109/nssmic.2003.1352254
(2003) ART with Linograms for PEM, Proc. 7th Portuguese Conference on Biomedical Engineering, p. 3-6
Book chapters
(2018) MR-PET Measurement, Hybrid MR-PET Imaging, p. 273-287