The paper “Targeting Triple-Negative Breast Cancer: A Special Focus on Phototherapy and Nanomaterials” was recently published in the journal Molecules.
This work was developed by a PhD student under the supervision of IBEB full member João Coelho, in collaboration with Prof. Catarina Reis and Dr. Manuela Gaspar from the Faculty of Pharmacy, University of Lisbon (FFUL).
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking estrogen, progesterone, and HER2 receptors. This characteristic limits the effectiveness of hormonal and targeted therapies, and despite advances in chemotherapy (ChT), radio therapy (RT), surgery, targeted therapy (TT) and immunotherapy (IT), clinical outcomes remain poor, highlighting an urgent need for new therapeutic strategies. The development of advanced nanotechnology-based strategies has opened new avenues for the diagnosis and therapy of TNBC. This review focuses on photothermal therapy (PTT) combined with nanotechnology-based strategies. As this innovative approach progresses toward clinical application, future studies and trials will be crucial in determining its potential for TNBC management and improving patient outcomes.
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